RESULTS
Search this site
13120 results found
- Safe and Effective Ways to Cover and Conceal Wounds After a Bicycle Accident
Being involved in a bicycle accident can involve some fairly traumatic injuries. Along with serious internal injuries and broken bones, you can also be dealing with scratches, cuts, abrasions, and bruising. Not only can these injuries be painful, but they can also be unsightly. You may even feel uncomfortable with the extra attention in your personal or professional life. Image by DepositPhotos To limit their visual impact, try these helpful tips and techniques: Seek Medical Attention If in a bicycle accident , you should always seek proper medical attention to determine the extent of your injuries. Not all injuries are immediately apparent, such as broken bones, internal damage, and a concussion. Seeking proper medical attention provides you with a medical report, which can prove helpful if you decide to take legal action. However, it can also lay a healthy foundation for healing. Healthcare professionals can clean and dress your wounds, check for fractures or head injuries, and prescribe or recommend safe treatments, like healing ointments. Heal At Home Once you’ve been released from a healthcare facility, you can begin the healing process and care for your wounds at home. The longer you stay at home, the more rest you can get, and the more healed your wounds are, to be less visible to others. Clean around your wounds gently with mild soap and water, and apply antibiotic ointments if recommended by a healthcare professional. If you’ve been prescribed any medication, follow the provided instructions. If you have swelling and bruises, use cold compresses and keep the area elevated. You can also promote healing by staying hydrated and eating foods rich in vitamins and minerals, such as protein and vitamin C . Use Specific Makeup Products If you need to head back to work or venture out in public, and you don’t want to draw attention to yourself, use medical-grade concealer or color-correcting makeup. Green tones in makeup reduce redness, while yellow and orange can neutralize purple and blue bruising. Concealers can work by fading bruises, making them less obvious to those around you. To prevent discoloration while healing, you may also see the value in wearing sunscreen . It works by blocking UV rays that can worsen bruising and cause post-inflammatory hyperpigmentation. Be Strategic with Clothing You won’t always be able to cover all bruises with makeup. That’s where clothing comes into play. If you have bruises and abrasions on your arms and legs from your bicycle accident that you want to hide, wear long sleeves and pants. In warmer weather, take care to ensure the materials are breathable for comfort. You should also avoid wearing tight fabrics over open wounds. If you have scrapes around your chin and neck area, a well-placed scarf may reduce their visibility. You can even hide facial injuries like scratches by changing how you style your hair. Image by DepositPhotos Take Care Of Your Hands Likely, your hands didn’t escape injury in a bicycle accident if they made contact with the road or footpath. You may be able to help them heal and make scrapes and bruises less obvious by wearing natural bandages or skin-tone medical tape. Prevent dryness by regularly applying hand cream. If you frequently shake hands or type, ensure your dressings aren’t bulky or prone to peeling. Covering and concealing your bicycle-related injuries can make you feel better in public settings. Some of these tips and tricks may assist with both healing and concealing for peace of mind. By ML Staff. Image courtesy of DepositPhotos
- Why Brazilian Jiu-Jitsu Lovers are Choosing these IBJJF-Approved GIs
Brazilian Jiu-Jitsu (BJJ) is a martial art that values precision, discipline, and technical mastery. When it comes to equipment, few things are as essential as the gi. A gi represents the practitioner's dedication to the craft, a silent partner in every roll and training session. While there are many gi brands available today, one brand stands out: Kingz. Known for their high-quality gear and strong presence in the BJJ community, Kingz continues to be a favorite among enthusiasts, from beginners to black belts. For those who want to compete at the highest levels, IBJJF approval is a must. The International Brazilian Jiu-Jitsu Federation (IBJJF) sets strict guidelines for competition gis, and Kingz has consistently met these standards. But what makes Kingz so popular among BJJ practitioners, especially when it comes to their IBJJF-approved gis? Why Fans Love Kingz Kingz has established itself as one of the most trusted names in the world of Brazilian jiu-jitsu apparel. Fans love the brand for several reasons: Durability : Kingz gis are known for their strength and durability. Using high-quality materials, such as the 380GSM Pearl Weave fabric for the jacket and 270GSM ripstop fabric for the pants, they are built to withstand the demands of rigorous training and competition. IBJJF Approval : Every Kingz gi is designed to meet the stringent requirements of the IBJJF. This means you can wear their gi with confidence in official competitions, knowing it’s both legal and optimal for performance. Comfort and Fit : Kingz understands that comfort is key in Brazilian Jiu-Jitsu. The brand offers a variety of cuts and fits to accommodate different body types, making sure that athletes of all shapes and sizes can find their ideal fit. Innovative Design : Kingz doesn’t just focus on functionality. Their designs are sleek and modern, often incorporating unique touches like the synthetic heat-resistant vulcanized lapel insert, which adds durability while also giving the gi a distinctive look. Athlete Endorsements : Kingz is proud to sponsor top-level BJJ athletes, including legends like Andre Galvao, Mackenzie Dern, and Leandro Lo. These athletes put their trust in Kingz, and that speaks volumes about the quality and performance of the gear. About Kingz Kingz is a brand that has deep roots in the BJJ community. Founded in 2011 by Bruno Munduruca, an accomplished competitor and founder of MMA Gear in Brazil, the brand quickly gained a reputation for creating high-quality, durable gi apparel. Based in San Diego, California, Kingz caters to both men and women with a wide range of designs, weights, and price points. What sets Kingz apart from many other brands is its dedication to innovation and authenticity. The founder, Bruno, is not just a businessman; he's an active participant in the BJJ community. He competes, tests the products himself, and stays connected to the culture of Brazilian Jiu-Jitsu. This involvement ensures that Kingz products are designed with both the beginner and elite athlete in mind. Beyond their reputation for producing excellent gis, Kingz is also known for their athlete sponsorships. Some of the sport's most iconic figures, such as Andre Galvao and Mica Galvao, wear Kingz on the mats. This connection to top-tier athletes reinforces the brand's credibility and authenticity in the eyes of fans and practitioners alike. The Kingz Gi: More Than Just Gear A gi isn't just a uniform; it's a symbol of the dedication and hard work that every BJJ practitioner puts into their training. As Saulo Ribeiro famously said, “Jiu-Jitsu at the end of the day is the art of expressing yourself honestly. Every time you put on that Gi you can’t lie.” For many, a gi represents not just the technical aspects of training but the personal journey they undergo in the process of mastering the art. Kingz gis are designed to accompany this journey. With features like triple-reinforced stitching at all stress points and custom, detailed stretchy drawstrings, Kingz ensures that the gi is as durable as the athlete who wears it. The material and craftsmanship used in every Kingz gi reflect the brand’s commitment to quality and its deep understanding of the BJJ culture. Their gis, such as the Ultralight Kimono and Kingz One, are crafted with meticulous attention to detail, making them a top choice for athletes who need gear they can rely on for both training and competition. Whether you're training for the next competition or refining your skills on the mats, Kingz has a gi that will support you through it all. IBJJF-Approved Features of Kingz Gis When it comes to BJJ competitions, especially at the IBJJF level, there’s no room for mistakes. Every detail matters, from the cut of the gi to the material it’s made from. Kingz has ensured that their gis meet every IBJJF requirement while also providing superior performance. Here’s a closer look at some of the key features that make Kingz gis ideal for competition: 380GSM Pearl Weave Fabric : The jacket of a Kingz gi is made from a durable 380GSM Pearl Weave fabric. This fabric is strong enough to withstand the intense pulls and grips common in BJJ, yet light enough to allow for the fluid movement that’s essential for top-tier performance. Synthetic Heat-Resistant Vulcanized Lapel Insert : The lapel is one of the most important parts of a BJJ gi, and Kingz has created an innovative heat-resistant vulcanized lapel insert. This ensures that the gi’s lapel doesn’t lose its form over time, making it much harder for opponents to grip and control during competition. Double Reinforced Knee Padding : The pants of a Kingz gi are reinforced with double knee padding, making them resistant to wear and tear even in the most intense training sessions. This added durability ensures the pants will hold up through countless rounds of sparring and competition. Custom Stretchy Drawstrings : Comfort and ease of use are essential when it comes to gi pants. Kingz features custom stretchy drawstrings, ensuring a secure fit without being too tight or uncomfortable. IBJJF 2024 Legal : Every Kingz gi is 100% IBJJF legal for 2024, meaning it complies with all the regulations set forth by the IBJJF, so athletes can wear their Kingz gear with confidence at competitions. Final Thoughts Kingz has cemented its place as one of the leading brands in the world of Brazilian Jiu-Jitsu apparel. From its commitment to producing high-quality, durable gear to its involvement with top athletes, the brand has earned the trust of the BJJ community. For those looking for an IBJJF-approved gi that stands up to the challenges of competition, Kingz is a clear choice. As the saying goes, “A black belt is just a white belt who never gave up.” Kingz is a brand that supports this ethos, offering gis that are reliable, durable, and built for success. If you’re looking to upgrade your BJJ gear and experience the quality of a trusted brand, check out the full range of Brazilian jiu-jitsu apparel offered by Kingz. Whether you’re a seasoned competitor or just starting your journey, Kingz has the right gi for you. By ML Staff
- Crew Miami’s “Lunch & Learn” Unites Female Leaders Addressing Affordable Housing Challenges
Commercial Real Estate Women Miami (CREW Miami) hosted its October Lunch & Learn , Shaping Miami’s Future: Expert Solutions for Affordable Housing , on Wednesday, October 15, 2025, at Mayfair House Hotel & Garden in Coconut Grove. The discussion brought together professionals from across South Florida for an in-depth conversation about one of the region’s most pressing issues—affordable housing. Left to right: Annie Lord, Executive Director, Miami Homes For All; Winell Belfonte, Partner, CohnReznick; Josie Legido Correa, 2025 CREW Miami President and Director of Business Development at JWR Construction Services; Heather Olson, Managing Director, Berkadia; Sydne Garchik, Principal, MRK Partners; Shannon Wilson, 2025 CREW Miami Programs Director and Associate Director at Berkadia. | Photo Credit Allegory PR Services “As a builder, we often face misconceptions about affordable housing,” said Josie Legido Correa, 2025 CREW Miami President and Director of Business Development at JWR Construction Services, who moderated the discussion. “These projects are well-designed, well-built, and an essential part of Miami’s future. It’s important that we continue to change the narrative around what affordable housing means for our community.” The panel featured Sydne Garchik , Principal, MRK Partners ; Heather Olso n, Managing Director, Berkadia ; Winell Belfonte , Partner, CohnReznick ; and Annie Lord , Executive Director, Miami Homes For All. Together, they explored financing, development, and policy strategies that could help close Miami-Dade County’s affordable housing gap. Annie Lord emphasized that public investment remains the most critical factor in addressing Miami-Dade’s housing shortage, noting that only large-scale public funding can bridge the affordability gap. Heather Olson outlined the complexity of the Low-Income Housing Tax Credit (LIHTC) process and shared examples of innovative employer-assisted housing initiatives, including The Breakers project in Palm Beach. Sydne Garchik spoke about the importance of education and transparency to overcome community resistance, noting that proactive communication helps build public trust and support. Winell Belfonte discussed emerging financial tools such as green bonds, impact investing, and corporate partnerships, underscoring the long-term collaboration needed to make these projects successful. Throughout the conversation, panelists encouraged collaboration between the public and private sectors and highlighted the need for advocacy, creative financing, and policy reform to sustain progress. “This panel brought together some of the most knowledgeable women in commercial real estate and community development,” added Josie Legido Correa. “Their collective expertise demonstrates that affordable housing isn’t just about construction—it’s about collaboration, education, and equity. That’s what CREW Miami stands for.” Looking Ahead 6th Annual CREW Miami Golf Tournament Friday, November 7, 2025 | 12:00–8:00 p.m. Miami Shores Country Club Event Details 2025 Holiday Party & Awards Wednesday, December 10, 2025 | 5:30–8:30 p.m. Lucid Art Gallery, 10 NE 41st Street, Miami, FL 33137 Event Link By ML Staff. Content/images courtesy of CREW Miami.
- The Nader Sculpture Park Celebrates the Arrival of Botero’s Mid-size Bronze Sculptures And Unveils First Monumental by Soraya Abunaba'a
The Nader Sculpture Park proudly announces a special evening celebrating the arrival of Fernando Botero’s mid-size sculptures , alongside the unveiling of “Chroma Emotiva” by Soraya Abunaba´a . This exclusive cocktail event embodies the spirit of the park, a space where the timeless legacy of Latin American masters converges with the creative pulse of today’s most compelling contemporary voices . The evening will open with a celebration of two powerful artistic visions. Fernando Botero’s timeless bronze sculptures reveal the harmony of form and volume that define his work, while Soraya Abunabaa’s mirrored sculpture invites viewers to explore a more introspective dialogue with nature, emotion, and the self. The collection of mid-size sculptures now arriving at the park features some of the most emblematic subjects from Botero’s celebrated career — female figures in repose, dancers in graceful motion, equestrian icons, and symbolic representations of animals — each exemplifying his mastery of form and rhythm. “Botero’s sculptures embody the soul of Latin American art —monumental yet deeply human,” says Gary Nader, founder of the Nader Sculpture Park. “They remind us that beauty and emotion can coexist in their purest form.” In harmony with this celebration, the Nader Sculptures Park will also unveil “Chroma Emotiva,” the first monumental sculpture by Soraya Abunaba´a . Inspired by her Flora series, the reflective stainless-steel piece explores the emotional language of flowers as symbols of gratitude, friendship, and hope. Its mirrored surfaces encourage viewers to see themselves within the work, reflecting our shared connection to nature and to one another. “This evening reflects the mission of the Nader Sculpture Park — to celebrate the excellence and diversity of Latin American art, where the legacy of masters like Botero meets the vision of emerging talents such as Soraya Abunabaa,” adds Nader. The unveiling event will take place on Thursday, October 30, 2025 , at Nader Sculpture Park (4201 NE 2nd Ave, Miami Design District, FL 33137). Attendance by invitation only. For more information: www.nadersculpturepark info@nadersculpturepark 305-576-0256 ML Staff. Content/images courtesy of Nader Sculpture Park
- Why CasinosAnalyzer Is Leading the Way in Transparent Casino Reviews
In the fast-paced world of online gambling, players need more than flashy promotions and exciting games – they need trust. With countless platforms competing for attention, transparency in casino reviews has become essential. CasinosAnalyzer stands at the forefront of this transformation, setting a new standard for honesty, accuracy, and accountability in casino evaluation. The platform’s commitment to clear, evidence-based reviews empowers players to make informed choices and avoid misleading or unsafe sites. By combining expert research with verified data, CasinosAnalyzer ensures every recommendation is grounded in fairness and real value. Image by DepositPhotos Whether players are looking for trusted operators, secure payment options, or rewarding offers like a 5€ no deposit bonus , CasinosAnalyzer provides the insights they need to gamble safely and confidently. In 2025 and beyond, its mission is clear: to bring transparency, integrity, and confidence to every player exploring the online casino world. By doing so, CasinosAnalyzer continues to redefine how users perceive online gambling – not as a risky or confusing environment, but as a transparent, fair, and enjoyable experience built on trust and verified information. Building Trust Through Verified Data The foundation of CasinosAnalyzer’s transparency lies in its reliance on verified data rather than marketing claims. Many casino review sites simply recycle promotional material, presenting biased or incomplete information. CasinosAnalyzer takes a radically different approach by performing independent research and verifying every claim made by the platforms it reviews. Every assessment goes beyond surface-level details to ensure that the information presented to users reflects real-world performance, not advertising spin. Licensing, ownership, payout performance, and game providers are all examined through official sources. This process also includes reviewing third-party audits, player feedback, and historical payout records to build a complete picture of each casino’s reliability. CasinosAnalyzer’s experts meticulously cross-check data to eliminate inconsistencies and ensure that only the most accurate details are included. This ensures players receive factual, verifiable insights instead of vague promises. Transparency begins with truth, and CasinosAnalyzer’s data-driven approach allows users to see exactly why a casino earns its ranking. By showing how every score is calculated and supported by evidence, CasinosAnalyzer builds genuine trust between players and the industry. The platform even invites users to explore independent feedback on Trustpilot , where its commitment to honesty and credibility is clearly reflected. This level of openness transforms casino reviews from mere opinions into a dependable, evidence-based resource for confident decision-making in the online gambling world. Transparent Methodology That Sets a New Standard What makes CasinosAnalyzer truly unique is its transparent review methodology. Each evaluation follows a strict framework that prioritizes safety, fairness, and reliability. The platform explains its criteria in clear terms, allowing players to understand precisely how ratings are determined. This level of transparency helps eliminate the ambiguity that often surrounds online casino reviews and reassures players that every ranking is based on facts, not marketing influence. To maintain consistency and objectivity, CasinosAnalyzer’s evaluation process is built around several key factors: Licensing and regulation: Verification of each casino’s authorization from trusted gaming commissions. Payout performance: Analysis of withdrawal speed, transaction reliability, and financial transparency. Game fairness: Confirmation that certified random number generators (RNGs) and independent audits are used. Bonus conditions: Review of wagering requirements, bonus clarity, and long-term player value. User feedback: Consideration of verified player reviews to measure satisfaction and trust. Security standards: Evaluation of encryption protocols, data protection measures, and responsible gambling tools. CasinosAnalyzer continuously refines its evaluation model based on player feedback and ongoing industry developments. This ensures that its transparency remains dynamic, relevant, and reflective of genuine user experience. Each update to the framework strengthens its credibility, providing players with insights they can rely on. As a result, users can trust that every review is both honest and current, reinforcing CasinosAnalyzer’s position as a leader in transparent and ethical casino reporting. Image by DepositPhotos Empowering Players with Clarity Transparency means nothing without practical value. CasinosAnalyzer goes beyond analysis to empower players with the clarity they need to make smart, confident decisions. The platform simplifies complex details – from bonus requirements to withdrawal terms – translating them into accessible insights that even new players can understand. Every review is designed to give a full picture of a casino’s strengths and weaknesses, helping users quickly grasp whether a platform is suitable for their preferences and style of play. Instead of overwhelming users with technical jargon, CasinosAnalyzer explains what each factor means for their actual gaming experience. For example, rather than simply listing a wagering requirement, the platform breaks down how it affects bonus usability, potential winnings, and realistic timelines for withdrawal. Similarly, payout methods are analyzed not only for availability but also for speed, reliability, and security, giving players practical knowledge that affects their day-to-day experience. By prioritizing the player’s perspective, CasinosAnalyzer turns transparency into empowerment. Users not only understand what to choose but also why. The platform also highlights recurring patterns in promotions and game quality, enabling players to recognize trustworthy casinos quickly and avoid misleading offers. This user-focused approach has made CasinosAnalyzer a trusted companion for millions seeking fairness, safety, and genuine value in online gambling. Ultimately, it bridges the gap between information and actionable insight, allowing players to enjoy their gaming experience with confidence and peace of mind. By ML Staff. Images courtesy of DepositPhotos
- B7-33 Peptide: A Streamlined Relaxin Analog with Far-Reaching Research Potential
The B7-33 peptide emerges as a uniquely structured peptidic analog that may redefine explorations into fibrosis, vascular modulation, and molecular scaffolding. Originating from the B-chain of H2-relaxin, this simplified, single-chain derivative might offer research domains a more accessible and tunable reagent. Its solubility enhancements, receptor selectivity, and signaling bias suggest it might potentially serve as a versatile tool across diverse investigative disciplines. Image by DepositPhotos Structural Composition and Receptor Engagement B7-33 is crafted from amino acids 7–29 of the B-chain of H2-relaxin, augmented with a KRSL tail to markedly boost solubility compared to earlier truncated forms. This streamlined design is believed to enable more efficient synthesis—rendering it more practical for prolonged research use. Critically, the peptide seems to interact selectively with the relaxin family peptide receptor 1 (RXFP1) and may preferentially initiate signaling via the ERK1/2 (pERK) pathway rather than the cAMP route commonly activated by full-length H2-relaxin. This biased signaling characteristic may allow researchers to dissect downstream molecular processes with greater precision. Antifibrotic Property and Extracellular Remodeling Research One of the compelling attributes of B7-33 is its apparent antifibrotic properties. Investigations indicate that the peptide may engage RXFP1-AT2 receptor heterodimers, possibly initiating pERK-mediated upregulation of matrix metalloproteinase-2 (MMP-2), which might ostensibly facilitate extracellular collagen turnover and mitigate fibrotic deposition. Moreover, researchers have posited that coatings incorporating B7-33, such as PLGA-based controlled-release platforms, might reduce fibrotic encapsulation over longer durations in research materials, potentially serving as an innovative interface in tissue-engineering and device coating domains. Vascular and Vasoprotective Research Implications B7-33 is inferred to retain significant vascular modulation properties of H2-relaxin but with a more targeted profile. Studies suggest that the peptide might promote vasodilatory modulation via RXFP1 engagement—possibly involving nitric oxide (NO) pathways or endothelium-derived hyperpolarizing factor mechanisms—though it is not believed to fully replicate cAMP-driven vasodilatory cascades. Specifically, research models suggest that B7-33 may support vasodilation in mesenteric vascular systems—mirroring the vascular outcomes of serelaxin analogs—without the need for extensive receptor promiscuity. This potential property may render it plausible for further examination in vascular tone regulation, endothelial responsiveness, and mechanistic pathways modulating systemic or localized vascular resistance in experimental settings. Cardioprotective and Remodeling Modulation Research Within models of ischemia-reperfusion and myocardial insult, B7-33 appears to preserve the contractile integrity of cardiac tissue under stress. Investigations indicate that the peptide may limit infarct-like remodeling by decreasing endoplasmic reticulum stress markers (e.g., GRP78) and preserving fractional shortening metrics in research parameters, suggestive of a cardioprotective influence. These findings could make B7-33 a promising investigational reagent in exploring the molecular underpinnings of myocardial resilience, repair mechanisms, and stress-induced remodeling without the complexity of full-length peptide analogs. Image by DepositPhotos Molecular Engineering and Scaffold Optimization Research efforts have been directed toward generating a minimal active scaffold based on B7-33. Substitutions, truncations, and structural modifications (e.g., alanine scanning, hydrocarbon stapling, Aib incorporation) have been explored to refine binding affinity to RXFP1 domains, especially within engineered constructs like 7BP. It is theorized that key residues such as R^B13, R^B17, and I^B20 are central to binding, and that maintaining structural flexibility may be critical for activation—highlighting the peptide's potential as a modular design template. This tunability positions B7-33 as a potential starting point for developing analogs with tailored receptor affinity, signaling bias, or half-life properties—all of which are valuable for biochemical tool development and receptor pharmacology investigations. Emerging Research Domains and Speculative Applications Beyond fibrosis and vascular modulation, B7-33 might be of speculative interest in regenerative biology, tissue engineering, and cellular resilience studies. By possibly promoting extracellular matrix turnover and modulating repair pathways, the peptide may potentially be integrated into scaffolds or biomaterial systems to interrogate interactions between cellular populations and remodeling environments. Moreover, the peptide's receptor specificity and signaling bias may allow exploration into inflammatory or stress response pathways—investigations into how RXFP1-mediated ERK activation may intersect with inflammatory or anti-hypertrophic signaling circuits could be particularly revealing. Summary and Outlook The B7-33 peptide may represent a compact, tunable, and functionally selective analog of H2-relaxin, offering research communities a streamlined reagent with intriguing properties, including: Enhanced solubility and synthesis feasibility RXFP1-selective bias toward pERK signaling rather than cAMP Putative antifibrotic remodeling through MMP-2 modulation Vasoprotective potential via non-cAMP pathways such as NO or EDH Preservation of contractile function under ischemic-like stress in models Amenability to structural refinement for receptor engagement studies Applicability in biomaterial coatings to attenuate fibrotic encapsulation By avoiding complexities linked to full-length relaxin, B7-33 seems to offer cleaner, mechanistic insights and may catalyze novel experimental frameworks in cardiovascular, fibrotic, and tissue-regenerative research contexts. Its modular nature and signaling precision position it as a versatile scaffold, perhaps serving as a linchpin in future explorations into GPCR biased agonism and extracellular remodeling dynamics. Researchers interested in further investigating the potential of this peptide are encouraged to visit this website for the best research materials and the most accurate peptide data available online. References [i] Stremming, J.W., Lok, M.C., Sundgren, N.C., White, F.M., & Duan, C. (2022). Human recombinant long arginine-3 IGF-1 (LR3 IGF-1) promotes organ-specific growth and myoblast proliferation in the fetal sheep. Frontiers in Physiology, 13 , Article 954948. https://doi.org/10.3389/fphys.2022.954948 . [ii] Hossain, M.A., Handley, T., Tailhades, J., Praveen, P., & Akhter, M. (2023). Further developments towards a minimal potent derivative of human relaxin-2. International Journal of Molecular Sciences, 24 (16), Article xxxx. https://doi.org/10.3390/ijms241612646 . [iii] Marshall, A.J., Tailhades, J., Handley, T., et al. (2016). B7-33, a functionally selective relaxin receptor 1 agonist, confers acute cardioprotection and limits myocardial infarction–related adverse remodeling in mice by attenuating cardiomyocyte death and endoplasmic reticulum stress. Journal of the American Heart Association, 5 (e015748). https://doi.org/10.1161/JAHA.119.015748 . [iv] Hossain, M.A., Marshall, A.J., et al. (2017). B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin): anti-fibrotic, vasodilatory, and anti-inflammatory effects. International Journal of Molecular Sciences, 18 (?–?) [v] Stremming, J. A., Brown, L., & Rozance, P. J. (Year). Effects of LR3 IGF-1 infusion on organ-specific growth and skeletal muscle myoblast proliferation in late-gestation fetal sheep. Frontiers in Physiology, Article ID, Volume (Issue). By ML Staff. Images courtesy of DepositPhotos
- Beyond the Horizon: "Ocean Paradise" Imax Takes Audiences to Unspoiled Pacific Atolls for Ecological Insight
Embark on an awe-inspiring journey across some of the most remote and pristine environments on Earth with the stunning new giant screen documentary, Ocean Paradise, opening October 24 at the AutoNation ® IMAX ® Theater at the Museum of Discovery and Science (MODS) . Viewers will be immersed in the breathtaking sights of islands, atolls and coral reefs on the far reaches of the Pacific Ocean—largely untouched by humans. Majestic manta rays glide through the Pacific alongside schools of fish in Ocean Paradise, a new IMAX® documentary opening October 24 at the AutoNation® IMAX® Theater at the Museum of Discovery and Science. Narrated by Diane Lane with both wonder and urgency, Ocean Paradise captures never-before-seen footage of extraordinary locations, including Palmyra Atoll within the Pacific Remote Islands Marine National Monument, Midway Atoll as part of Papahānaumokuākea Marine National Monument and Rose Atoll Marine National Monument in American Samoa. Audiences will be transported into a world of dazzling wildlife, crystal-clear waters and tropical beauty, while learning about the vital role these places play in maintaining the health of our planet. The film also explores the storied past of these atolls—from their pivotal role in the WWII Pacific Theater to today’s cutting-edge ecological research and conservation initiatives. U.S. Fish and Wildlife Service biologists care for a Laysan albatross chick on Midway Atoll, one of the vital ecosystems featured in Ocean Paradise. " Ocean Paradise is more than just a visual spectacle—it is a reminder of what’s at stake as climate change, rising sea levels and plastic pollution threaten these fragile ecosystems," said Joseph P. Cox, president and CEO of MODS . "We are proud to bring this important story to our community and share the wonder of nature left untouched by civilization." Produced by Giant Screen Films in collaboration with the U.S. Fish and Wildlife Service, Ocean Paradise highlights the beauty, history and environmental significance of these marine national monuments. The film underscores how vital it is to care for such fragile ecosystems—now and for generations to come. A vibrant school of convict surgeonfish surrounds coral reefs in the Pacific, one of the thriving underwater ecosystems showcased in Ocean Paradise. “Giant Screen Films is thrilled to be launching Ocean Paradise . The film combines exceptional cinematography for the giant screen with impactful storytelling and environmental messaging,” said Mark Katz, SVP of film distribution . “Diane Lane, a passionate ocean conservation advocate, delivers a truly heartfelt narration and the familiar songs of Coldplay and Jack Johnson are artfully employed by the filmmakers to create an excellent overall pacing. We expect Ocean Paradise to be a huge box office success for theaters in the years ahead.” A Laysan albatross tends to its chick on Midway Atoll, one of the vital seabird habitats featured in Ocean Paradise. The AutoNation ® IMAX ® Theater at the Museum of Discovery and Science is located at 401 SW 2nd Street in Fort Lauderdale. The film Ocean Paradise is included in the MODS Discovery Pass, an all-in-one ticket that includes Museum exhibitions, live science demonstrations and one IMAX ® documentary film. For tickets, please visit mods.org/tickets and for showtimes, please visit mods.org/showtimes . By ML Staff. Content courtesy of MODS. All photos courtesy of Giant Screen Films
- How Cannabis & Psilocybin Might Help Some of the 50 Million Americans Who are Experiencing Chronic Pain
The U.S. Drug Enforcement Agency announced in late April 2024 that it plans to ease federal restrictions on cannabis , reclassifying it from a Schedule I drug to the less restricted Schedule III, which includes drugs such as Tylenol with codeine, testosterone and other anabolic steroids . This historic shift signals an acknowledgment of the promising medicinal value of cannabis . Matteo Vistocco/Unsplash The move comes in tandem with growing interest in the use of psilocybin, the active component in magic mushrooms, for treatment of depression , chronic pain and other conditions . In 2018 and 2019, the U.S. Food and Drug Administration granted a breakthrough therapy designation to psilocybin , meant to expedite drug development given that preliminary studies suggest it may have substantial therapeutic value over currently available therapies for treatment-resistant depression and major depressive disorder . Both of these developments represent a dramatic change from long-standing federal policy around these substances that has historically criminalized their use and blocked or delayed research efforts into their therapeutic potential. As an assistant professor of anesthesiology and a pain researcher, I study alternative pain management options , including cannabis and psychedelics. I also have a personal stake in improving chronic pain treatment: In early 2009 I was diagnosed with fibromyalgia , a condition characterized by widespread pain throughout the body, sleep disturbances and generalized sensory sensitivity. I see cannabis and psilocybin as promising therapies that can contribute to bridging that need. Given that an estimated 50 million Americans have chronic pain – meaning pain that persists for three months or more – I want to help understand how to effectively use cannabis and psilocybin as potential tools for pain management. Cannabis versus other pain medications Cannabis , also known as marijuana, is an ancient medicinal plant. Cannabis-based medicines have been used for at least 5,000 years for applications such as arthritis and pain control during and after surgery. This use extended through antiquity to modern times, with contemporary cannabis-based medications for treating certain seizure disorders , promoting weight gain for HIV/AIDS-related anorexia and treating nausea during chemotherapy . As with anything you put in your body, cannabis does have health risks: Driving while high may increase risk of accidents. Some people develop cyclical vomiting , while others develop motivation or dependence problems , especially with heavy use at younger ages . That said, lethal overdoses from cannabis are almost unheard of . This is remarkable considering that nearly 50 million Americans use it each year . In contrast, opioids, which are often prescribed for chronic pain, have contributed to hundreds of thousands of overdose deaths over the past few decades. Even common pain medications like nonsteroidal anti-inflammatory drugs, such as ibuprofen, cause tens of thousands of hospitalizations and thousands of deaths each year from gastrointestinal damage. Furthermore, both opioids and nonopioid pain medications have limited effectiveness for treating chronic pain. Medications used for chronic pain can provide small to moderate pain relief in some people, but many ultimately cause side effects that outweigh any gains. These safety issues and limited benefit have led many people with chronic pain to try cannabis as a chronic pain treatment alternative. Indeed, in survey studies , my colleagues and I show that people substituted cannabis for pain medications often because cannabis had fewer negative side effects . However, more rigorous research on cannabis for chronic pain is needed. So far, clinical trials – considered the gold standard – have been short in length and focused on small numbers of people . What’s more, my colleagues and I have shown that these studies employ medications and dosing regimes that are far different from how consumers actually use products from state-licensed cannabis dispensaries. Cannabis also causes recognizable effects such as euphoria, altered perceptions and thinking differently, so it is difficult to conduct double-blind studies . Despite these challenges, a group of cannabis and pain specialists published a proposed guideline for clinical practice in early 2024 to synthesize existing evidence and help guide clinical practice. This guideline recommended that cannabis products be used when pain is coupled with sleep problems, muscle spasticity and anxiety. These multiple benefits mean that cannabis could potentially help people avoid taking a separate medication for each symptom. Photo/Wix Media Traditional hurdles to studying cannabis Since the Controlled Substance Act was passed in 1970, the federal government has designated cannabis as a Schedule I substance , along with other drugs such as heroin and LSD. Possession of these drugs is criminalized, and under the federal definition they have “no currently accepted medical use, with a high potential for abuse.” Because of this designation and the limits placed on drug manufacturing, cannabis is very difficult to study . State and federal regulatory barriers also delay or prevent studies from being approved and conducted. For example, I can purchase cannabis from state-licensed dispensaries in my hometown of Ann Arbor, Michigan. As a scientist, however, it is very challenging to legally test whether these products help pain . Reclassifying cannabis as a Schedule III drug has the potential to substantially open up this research landscape and help overcome these barriers. Psilocybin occurs naturally in many species of fungi, primarily mushrooms. Raphael Rangel/Getty Images The emerging role of psychedelics Psychedelics, such as psilocybin-containing mushrooms, occupy an eerily similar scientific and political landscape as cannabis. Used for thousands of years for ceremonial and healing purposes , psilocybin is also classified as a Schedule I drug. It can cause substantial changes in sensory perception, mood and sense of self that can lead to therapeutic benefits. And, like cannabis, psilocybin has minimal risk of lethal overdose . Clinical trials combining psilocybin with psychotherapy in the weeks before and after taking the drug report substantial improvements in symptoms of psychiatric conditions such as treatment-resistant depression and alcohol use disorder . Risks are typically psychological. A small number of people report suicidal thoughts or self-harm behaviors after taking psilocybin. Some also experience heightened openness and vulnerability , which can be exploited by therapists and lead to abuse . There are few published clinical trials of psilocybin therapy for chronic pain, although many are ongoing , including a pilot study for fibromyalgia conducted by our team at the University of Michigan. This treatment may help people develop a healthier relationship with their pain by eliciting greater acceptance of it and decreasing rumination often related to negative thoughts and feelings around pain. As with cannabis, some states, such as Colorado and Oregon , have decriminalized psilocybin and are building infrastructure to increase accessibility to psilocybin-assisted therapy. One recent analysis suggests that if psychedelics follow a similar legalization pattern to cannabis, the majority of states will legalize psychedelics between 2034 and 2037 . Challenges ahead These ancient yet relatively “new” treatments offer a unique glimpse into the messy intersection of drugs, medicine and society. The justifiable excitement about cannabis and psilocybin has led to state policies that have increased access for some people, yet federal criminalization and substantial barriers to scientific investigation remain. In the years ahead, I hope to contribute toward pragmatic studies that work within these difficult parameters. For example, our team developed a coaching intervention to help veterans use commercially available cannabis products to more effectively treat their pain. Coaches emphasize how judicious use can minimize side effects while maximizing benefits. Should our approach work, health care providers and cannabis dispensaries everywhere could use this treatment to help clients in chronic pain. Approaches like these can supplement more traditional clinical trials to help researchers determine whether these drug classes offer benefit and whether they have comparable or less harm than current treatments. As our society connects to the rich history of healing using these ancient drugs, these proposed changes may offer safer and substantive options for the 50 million Americans living with chronic pain. Kevin F. Boehnke Assistant Professor of Anesthesiology, University of Michigan. Special thanks to The Conversation. Donate and support today.
- Miami Premiere of CLUE – A Hilarious Whodunit at the Arsht Center
The Adrienne Arsht Center for the Performing Arts of Miami-Dade County and Broadway Across America will present the Miami premiere of CLUE , the laugh-out-loud murder mystery comedy inspired by the beloved board game and 1985 Paramount Pictures film. The show runs December 2–7, 2025 , at the Ziff Ballet Opera House . Directed by Broadway’s Casey Hushion ( Mean Girls , The Prom , Aladdin ), CLUE invites audiences to Boddy Manor, where six eccentric guests gather for an unforgettable evening of mystery, murder, and mayhem. As secrets unravel, everyone becomes a suspect—was it Mrs. Peacock in the study with the knife , or Colonel Mustard in the library with the wrench ? Celebrating 76 years since the board game’s debut in 1949, CLUE blends slapstick comedy with suspense, paying homage to a pop culture classic that has sold over 200 million copies worldwide. Ticket Information Tickets range from $48–$177 and are available now at ArshtCenter.org or by calling (305) 949-6722. Opening night on December 2 will feature an Arsht Plus pre-show experience at 6:30 p.m., including artist conversations, live entertainment, and interactive activities. The Arsht Center also offers accessible seating, assistive listening devices, and select performances with sign language interpretation, open captioning, and audio description. Cast and Creative Team The cast features Sarah Mackenzie Baron (Mrs. White) , Adam Brett (Wadsworth) , Camille Capers (Miss Scarlet) , Nate Curlott (Colonel Mustard) , Joseph Dalfonso (Mr. Boddy) , TJ Lamando (Mr. Green) , Madeline Raube (Mrs. Peacock) , and Kyle Yampiro (Professor Plum) , among others. Written by Sandy Rustin (based on the screenplay by Jonathan Lynn), CLUE includes additional material by Hunter Foster and Eric Price, with original music by Michael Holland. The production features scenic design by Lee Savage, costumes by Jen Caprio, lighting by Ryan J. O’Gara, sound by Jeff Human, and wigs/makeup by J. Jared Janas. More on CLUE The Second North American Tour of CLUE is produced by Work Light Productions and LME Productions , originally developed at Bucks County Playhouse and Cleveland Playhouse . CLUE continues the 2025–26 Broadway in Miami season, presented by Florida Theatrical Association in association with the Adrienne Arsht Center, with generous support from Bank of America. For showtimes, tickets, and updates, visit ArshtCenter.org . By ML Staff. Photo/CLUE
- Dior Autumn-Winter 2025/2026: A Quiet Revolution in Motion
Maria Grazia Chiuri’s Autumn-Winter 2025-2026 collection for Dior reimagines the house’s iconic codes with quiet confidence. From softened Bar jackets and flowing pleated skirts to robe-like coats and grounded tones of navy, gray, and ivory, the collection blends elegance with ease—crafted for a woman who leads with subtle strength. Fabrics like cashmere, organza, and velvet moved with grace, while delicate embroidery and practical accessories reinforced the message: beauty with purpose. Set against a minimalist, poetic backdrop in Paris, the show unfolded with contemplative calm. Chiuri’s vision of modern femininity doesn’t shout—it resonates. In a world of loud trends, Dior’s latest collection speaks clearly: timeless power lies in restraint. Explore the full collection at www.dior.com By ML Staff. Photos courtesy of Dior.
- Explore the Wolfsonian–FIU Current and Upcoming Exhibitions
Located in the heart of South Beach, The Wolfsonian–FIU invites visitors to explore a dynamic collection of art, design, and cultural exhibits that celebrate creativity and innovation. Admission is free for Florida residents , making it an accessible destination for locals and visitors alike. The museum is open Wednesday through Sunday from 10 a.m. to 6 p.m. , with extended hours until 9 p.m. on Fridays . As schedules and exhibits may change, be sure to visit wolfsonian.org for the latest updates and event details. World’s Fairs: Visions of Tomorrow N ow On View Through March 1, 2026 Featuring Wolfsonian collection works such as posters, books, souvenirs, and one of the first consumer TVs, World's Fairs: Visions of Tomorrow spotlights the centerpiece pavilions, spellbinding attractions, and uplifting themes that drew millions to cities from Paris to Spokane, often during times of crisis and change. Harry Clarke and the Geneva Window Ongoing Harry Clarke was commissioned in 1926 to create a window as a gift to the League of Nations in Geneva. The completed window was rejected—labeled too provocative and "unrepresentative" of the Irish people. This new installation sheds light on the life and times of Harry Clarke, the stories behind the window, and the consequences of cultural censorship. Modern Design Across Borders November 20, 2025–June 28, 2026 Modern Design Across Borders examines the cross-cultural web of connections among people, ideas, and movements that made modern design's remarkable reach and lasting impact possible. Focusing on five subjects within the story of interwar design—transportation, the 1925 Paris Expo, tea and coffee, plywood, and cocktail culture—the exhibition homes in on innovation and trends that spread from country to country, expressing progress and new ideals. La Superba: Genoa and The Wolfsoniana November 20, 2025–June 28, 2026 Genoa—home to The Wolfsoniana, The Wolfsonian's sister institution in Italy—is an ancient port city with a distinct character. Known as "La Superba" (the superb), Genoa and its Riviera have long drawn artists and writers from around the world. Through paintings, travel posters, postcards, books, and decorative arts from our collection, this installation provides a picture of Genoa as a mercantile and financial center in the first half of the 20th century. Marco Brambilla: After Utopia November 26, 2025–March 1, 2026 A video installation by contemporary artist Marco Brambilla, Marco Brambilla: After Utopia explores how we grapple with ideas about the future. Brambilla uses artificial intelligence (AI) and computer graphics (CG) to construct virtual landscapes inspired by world's fairs, combining and animating images of iconic structures from 19th-, 20th-, and 21st-century expositions. ML Staff. Content/images courtesy of Exhibitions at The Wolfsonian–FIU
- Beyond Miami: Mandarin Oriental Launches “Exclusive Journeys” — Curated Global Experiences for the Culturally Curious
For those looking to experience something beyond Miami’s beaches and nightlife, Mandarin Oriental invites travelers into a world of deeper discovery with the launch of Mandarin Oriental Exclusive Journeys — a growing collection of expertly curated experiences designed exclusively for guests of Mandarin Oriental hotels around the world. Each journey combines privileged access, cultural insight, and the brand’s renowned service to transform travel into something extraordinary. Developed in collaboration with The Luminaire , curators of knowledge-led travel, the Exclusive Journeys collection unfolds across Mandarin Oriental hotels in Madrid , Muscat , Paris , Milan , Geneva , Tokyo , and London . Every itinerary offers private access to cultural figures, institutions, and hidden places that reveal the authentic heart of each destination — places few travelers ever see.' From crossing Oman’s desert dunes with Bedouin guides to sampling rare vintages in 300-year-old Champagne cellars , these journeys are designed for private groups and led by experts in their fields. Each experience is fully customized, drawing on the local knowledge of Mandarin Oriental’s concierge teams and The Luminaire’s global network of scholars, curators, and storytellers. Now, the Exclusive Journeys collection arrives in the Americas for the first time at Mandarin Oriental, New York , where art, culture, and design come together in a series of new experiences that turn the city — and its surroundings — into a living gallery. These journeys invite guests to experience New York’s creative pulse from a completely new perspective. Highlights include: From Skyline to Shoreline: New York and Cape Cod – Take flight on a private seaplane for a four-day escape from Manhattan to Cape Cod , complete with a guided photography masterclass along the Cape Cod National Seashore . An Art Collector’s Day in Gilded Age New York – Step into the refined world of Klimt and Schiele with private access to the Neue Galerie and a behind-the-scenes tour at Sotheby’s or Christie’s . Chelsea to SoHo: Art, Music and Subculture – Follow New York’s creative heartbeat through private gallery visits and a tailored talk on Basquiat’s enduring influence. Modernism in Motion: From Manhattan to the Hudson – Journey from MoMA’s archives to the vast outdoor installations at Dia Beacon and Storm King Art Center , guided by leading curators and art historians. New York Photography Legends in Focus – Gain rare insight into contemporary photography through private sessions with leading figures such as Joel Meyerowitz’s longtime Archive Director or artist Liz Nielsen in her Hudson Valley studio. These experiences build upon Mandarin Oriental, New York’s cultural legacy, which includes exclusive access to Broadway , Jazz at Lincoln Center , Frieze New York , and the New York Film Festival . “These journeys reflect the spirit of Mandarin Oriental — our heritage of meaningful hospitality and our belief that luxury should deepen a guest’s understanding of place and culture,” said Andrew Cleary , Vice President of Customer Experience at Mandarin Oriental . “Today’s discerning travelers seek context and connection. With Exclusive Journeys , we offer encounters that are not only personal and inspiring, but also profoundly human.” Mandarin Oriental Exclusive Journeys will continue to expand across the brand’s global portfolio, each experience crafted in collaboration with experts who share Mandarin Oriental’s passion for excellence, exploration, and cultural connection. For more information or to reserve a journey, visit mandarinoriental.com/the-luminaire . Led by CEO Adam Sebba and CMO Nicholas Priest , formerly of Aman Resorts and One&Only Resorts , The Luminaire continues to redefine purposeful, knowledge-led travel. Website : theluminaire.com . Instagram: @theluminairetravel. By ML Staff. Photos/Mandarian Oriental












